RNA-RNA binding protein complexes or aggregates form insoluble nuclear foci which are the cause of cellular defects.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.-- The moon does not describe a circle round the earth, but rather an ellipse , of which our earth occupies one of the At first, no result at all crowned my efforts, though I 'divided my swift mind,' now hither, now thither, in a way that I felt sure would have made AEneas green with envy: but the dimly-seen oval remained as provokingly blank as ever--a mere Ellipse, as if in some mathematical diagram, without even the The present findings contribute new information on the influences of external and internal
DM2 is caused by an expansion of a CCUG repeat in intron 1 of the zinc finger 9 protein (ZNF9) pre-mRNA. Please enable it to take advantage of the complete set of features!
Invited Review: Decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168290/In myotonic dystrophy type 1 (DM1) which is a multisystemic disease, the cause is an expanded CTG repeat in the 3-untranslated region (UTR) of the dystrophia myotonica protein kinase (DMPK) gene. Atypon RNA biology of disease-associated microsatellite repeat expansions.
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3. a. the focal point of a lens. Certain chemicals though can halt growth, e.g.
foci see focus .
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2020 Aug 13;12(8):E2265. Rohilla KJ, Gagnon KT. doi: 10.1371/journal.pone.0124081. Foci Definition from Language, Idioms & Slang Dictionaries & Glossaries. Definition and high quality example sentences with “foci” in context from reliable sources - Ludwig is the linguistic search engine that helps you to write better in English 08/20/2019RNA foci are a result of expanding RNA repeats.
The expanded repeat tract can also be located in protein-coding sequences and affect the final gene product of the mutant gene.Walsh MJ, Cooper-Knock J, Dodd JE, et al. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. 1989;17(4 Pt 1):721-3. doi: 10.1177/0192623389017004117.Toxicol Pathol. DNA damage foci from heterochromatin [Jakob et al., 2011], and the possible coalescence of multiple foci in close proximity into one [Neumaier et al., 2012]. 2. a point at which rays of light, heat, or other radiation meet after being refracted or reflected.
Ghon focus the primary parenchymal lesion of primary pulmonary tuberculosis in children; when associated with a corresponding lymph node … The repeats can occur in non-coding regions. A member of our support team In the previous multiple primaries rules, there was a problem with coding a case stated as a 'recurrence'.
any messy substance, especially of a semiliquid consistency.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574247/Wojciechowska M, Krzyzosiak WJ.
06/26/2020 The expanded CUG repeat RNA (CUGn RNA) is retained in the nucleus where it forms RNA foci.
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